کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1216617 967027 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Standardizing GC–MS metabolomics
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Standardizing GC–MS metabolomics
چکیده انگلیسی

Metabolomics being the most recently introduced “omic” analytical platform is currently at its development phase. For the metabolomics to be broadly deployed to biological and clinical research and practice, issues regarding data validation and reproducibility need to be resolved. Gas chromatography–mass spectrometry (GC–MS) will remain integral part of the metabolomics laboratory. In this paper, the sources of biases in GC–MS metabolomics are discussed and experimental evidence for their occurrence and impact on the final results is provided. When available, methods to correct or account for these biases are presented towards the standardization of a systematic methodology for quantitative GC–MS metabolomics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 871, Issue 2, 15 August 2008, Pages 191–201
نویسندگان
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