Doehlert uniform shell designs and chromatography

The principles of the Doehlert uniform shell designs (aka Doehlert designs) and their importance in the context of chromatography are discussed. The confidence of different models generated by Doehlert designs is studied by means of the uncertainty of the experimental points. The article provides an overview of analytical applications in chromatography with focus on single and coupled techniques and also discusses some reported blunders regarding Doehlert designs.

► Review of the principles and application of Doehlert designs in chromatography.
► Critical discussion of the reported misconceptions regarding Doehlert designs.
► Estimation of the associated uncertainties generated by Doehlert designs.