کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1216822 1494194 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determination of celecoxib in human plasma and breast milk by high-performance liquid chromatographic assay
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Determination of celecoxib in human plasma and breast milk by high-performance liquid chromatographic assay
چکیده انگلیسی

A rapid and simple HPLC assay was developed for the determination of celecoxib in human plasma and breast milk. After proteins were precipitated with acetonitrile, celecoxib was resolved on a C18 column and detected by UV detection at 254 nm. Standard curves were linear over the concentration range 10–2000 μg/L (r2 > 0.99). Bias was ≤±15% from 20 to 2000 μg/L in both matrices, intra- and inter-day coefficients of variation (imprecision) were <10%, and the limit of quantification was 10 μg/L.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 830, Issue 2, 18 January 2006, Pages 245–248
نویسندگان
, , , ,