کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1216822 | 1494194 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination of celecoxib in human plasma and breast milk by high-performance liquid chromatographic assay
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
A rapid and simple HPLC assay was developed for the determination of celecoxib in human plasma and breast milk. After proteins were precipitated with acetonitrile, celecoxib was resolved on a C18 column and detected by UV detection at 254 nm. Standard curves were linear over the concentration range 10–2000 μg/L (r2 > 0.99). Bias was ≤±15% from 20 to 2000 μg/L in both matrices, intra- and inter-day coefficients of variation (imprecision) were <10%, and the limit of quantification was 10 μg/L.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 830, Issue 2, 18 January 2006, Pages 245–248
Journal: Journal of Chromatography B - Volume 830, Issue 2, 18 January 2006, Pages 245–248
نویسندگان
Mei Zhang, Grant A. Moore, Sharon J. Gardiner, Evan J. Begg,