کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1217187 | 1494185 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of a gradient reversed-phase HPLC method for the determination of sodium ferulate in beagle dog plasma
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Development of a gradient reversed-phase HPLC method for the determination of sodium ferulate in beagle dog plasma Development of a gradient reversed-phase HPLC method for the determination of sodium ferulate in beagle dog plasma](/preview/png/1217187.png)
چکیده انگلیسی
A gradient reversed-phase HPLC assay has been developed to determine sodium ferulate (SF) in beagle dog plasma with tinidazole as an internal standard. Chromatographic separation was made on a C18 column using 0.5% acetic acid and acetonitrile (80:20, v/v) as mobile phase. UV detection was performed at 320 nm. The calibration curve for SF was linear in the range of 0.05–10 μg/ml, and the achieved limit of quantification (LOQ) was 51.4 ng/ml. The results of linearity, within- and between-day precision, and accuracy demonstrate that this method is reliable, sensitive and sufficient for in vivo beagle dog pharmacokinetic (PK) studies of SF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 846, Issues 1–2, 1 February 2007, Pages 319–322
Journal: Journal of Chromatography B - Volume 846, Issues 1–2, 1 February 2007, Pages 319–322
نویسندگان
Feng-Qian Li, Shu Xu, Hua Su, Jia-Xin Deng, Ji-Yong Liu, Jin-Hong Hu,