کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1217552 | 967112 | 2009 | 5 صفحه PDF | دانلود رایگان |

The determination of benzophenones (BPs) in human urine sample by miniaturized hollow fiber assisted liquid-phase microextraction (HF-LPME) and gas chromatography–mass spectrometry (GC–MS) is described. As analytes, BP, its metabolites benzhydrol (BP-OH) and 2-hydroxybenzophenone (2OH-BP), and its derivatives 2-hydroxy-4-methoxybenzophenone (BP-3) and 2-hydroxy-4-methoxy-4′-methylbenzophenone (BP-10) were selected. The detection limit and the quantification limit of BPs in human urine sample are 5–10 and 20–50 pg mL−1, respectively. The calibration curve for BPs is linear with correlation coefficient higher than 0.99 in the range of 0.02–10 or 0.05–10 ng mL−1. The average recoveries of BPs in human urine samples spiked with 0.5 and 5 ng mL−1 BPs are 89.8–100.2% (RSD: 2.5–9.3%) and 89.3–99.9% (RSD: 2.9–3.7%), respectively. Ten human urine samples were analyzed using the present method. BP-OH and BP-3 were detected in all the samples within the range of 0.24–5.91 and 0.43–5.17 ng mL−1, respectively. This simple, sensitive, and selective analytical method was successfully applied to the determination of trace amounts of BPs in human urine samples.
Journal: Journal of Chromatography B - Volume 877, Issue 3, 15 January 2009, Pages 298–302