کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1217618 | 967126 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A development of LC–MS method combining ultrafiltration and lyophilization for determination of r-RGD-Hirudin in human serum
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A development of LC–MS method combining ultrafiltration and lyophilization for determination of r-RGD-Hirudin in human serum A development of LC–MS method combining ultrafiltration and lyophilization for determination of r-RGD-Hirudin in human serum](/preview/png/1217618.png)
چکیده انگلیسی
A reliable and validated LC–MS method was established for determination of r-RGD-Hirudin in human serum. Ultrafiltration was used instead of liquid–liquid extraction or solid phase extraction for water solubility drug r-RGD-Hirudin extraction. Freeze drying was used for concentration. The experiment conditions, including pre-processing procedure and LC–MS, have been investigated and optimized. Comparing with reported assays, the current method showed significant improvement in specificity, linearity, precision and sensitivity. This method has been successfully applied in clinical research of r-RGD-Hirudin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 870, Issue 1, 1 July 2008, Pages 27–31
Journal: Journal of Chromatography B - Volume 870, Issue 1, 1 July 2008, Pages 27–31
نویسندگان
Shengmin Su, Yunqiu Yu, Wei Mo, Yanling Zhang, Houyan Song, Qinfen Chen, Yi Xie,