کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1217858 | 1494184 | 2007 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Statistics for proteomics: Experimental design and 2-DE differential analysis
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Statistics for proteomics: Experimental design and 2-DE differential analysis Statistics for proteomics: Experimental design and 2-DE differential analysis](/preview/png/1217858.png)
چکیده انگلیسی
Proteomics relies on the separation of complex protein mixtures using bidimensional electrophoresis. This approach is largely used to detect the expression variations of proteins prepared from two or more samples. Recently, attention was drawn on the reliability of the results published in literature. Among the critical points identified were experimental design, differential analysis and the problem of missing data, all problems where statistics can be of help. Using examples and terms understandable by biologists, we describe how a collaboration between biologists and statisticians can improve reliability of results and confidence in conclusions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 849, Issues 1–2, 15 April 2007, Pages 261–272
Journal: Journal of Chromatography B - Volume 849, Issues 1–2, 15 April 2007, Pages 261–272
نویسندگان
Jean-François Chich, Olivier David, Fanny Villers, Brigitte Schaeffer, Didier Lutomski, Sylvie Huet,