کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1219517 | 1494543 | 2016 | 11 صفحه PDF | دانلود رایگان |
• Effect of HMLE on DSS-induced colitis in mice was assessed.
• HMLE regulated the production of NO, MPO, TNF-α, IL-1β, IL-6, and IL-10.
• The mechanism might rely on the modulation of the TLR-4/NF-κB pathway.
• Overall effect was comparable with standard anti-inflammatory drug SASP.
The anti-inflammatory effect of a lipid extract from hard-shelled mussel (HMLE) on dextran sulphate sodium (DSS)-induced colitis in mice was investigated. Salicylazosulphapyridine (SASP) and different doses of HMLE were administered by gastric gavage. HMLE significantly attenuated DSS-induced colitis disease activity index scores, tissue damage, splenic enlargement and colon myeloperoxidase accumulation. In addition, HMLE improved colon oxidative stress and production and expression of anti-inflammatory cytokine, interleukin (IL)-10, while HMLE inhibited the abnormal productions and mRNA expressions of pro-inflammatory cytokines, namely tumour necrosis factor-α, IL-1β, and IL-6, as well as the expression of key molecules in the toll-like receptor (TLR)-4/nuclear factor (NF)-κB signalling pathway. These findings suggest that HMLE has an anti-inflammatory effect on DSS-induced colitis, equivalent to that of SASP, and this effect might be related to the regulation of inflammatory mediators and key molecules in the TLR-4/NF-κB pathway.
Journal: Journal of Functional Foods - Volume 23, May 2016, Pages 389–399