Lignan glycosides from sesame meal exhibit higher oral bioavailability and antioxidant activity in rat after nano/submicrosizing

• Oral bioavailability of sesaminol triglucoside increased after nanosizing.
• Nanoparticles improved bioaccessibility of sesame meal to intestinal microbiota.
• Nano/submicrosized lignan glycosides alleviated lipid peroxidation in rat.
• Nano/submicrosized lignan glycosides increased antioxidant enzyme activities in rat.

Lignan glycosides are one of the major bioactive components in sesame meal. In the current study, we evaluated whether the absorption efficiency of lignan glycosides from sesame meal (LGSM) increases after wet milling. The current data show that oral bioavailability of LGSM significantly elevated from 0.18 to 0.26% after nano/submicro-sizing due to the smaller particle size and larger surface area. Oral administration of nano/submicro-sized LGSM (N-LGSM) significantly increased the concentrations of sesaminol triglucoside and sesaminol glucuronide in rat urine compared to administration of LGSM that was not nano/submicro-sized. More importantly, oral administration of N-LGSM increased the concentrations of enterolactone and enterodiol found in the plasma, liver, kidney, small intestine and urine of rats, suggesting that the nano/submicro-sizing process greatly improved the accessibility of intestinal microbiota to LGSM. In addition, oral administration of N-LGSM remarkably alleviated lipid peroxidation and increased antioxidant enzyme activities against tert-butyl hydroperoxide-induced oxidative damage in rats.