کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1219592 967720 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fungal immunomodulatory proteins alleviate docetaxel-induced adverse effects
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Fungal immunomodulatory proteins alleviate docetaxel-induced adverse effects
چکیده انگلیسی


• FIP-gts reversed docetaxel-induced decrease in white blood cells (WBC).
• FIP-fve and FIP-gts reduce docetaxel-induced empty vacuoles in bone marrow and damage to small intestinal mucosa.
• The FIP-fve and FIP-gts supplementation prevented 30 mg/kg docetaxel-induced bone damage.
• FIP-fve and FIP-gts diminish MCP-1 production and mRNA expression in A549 cells.

Docetaxel is widely used in the treatment of non-small cell lung cancer. Fungal immunomodulatory proteins of Flammulina velutipes (FIP-fve) and Ganoderma tsugae (FIP-gts) possess immunomodulatory and anti-cancer effects. The abilities of FIP-fve and FIP-gts to protect against docetaxel-induced adverse effects were investigated. FIP-gts, but not FIP-fve, reversed docetaxel-induced decrease in white blood cells (WBCs). On haematoxylin and eosin (H & E), FIP-fve and FIP-gts reduced docetaxel-induced empty vacuoles in bone marrow and damage to small intestinal mucosa. On 3D micro-CT analysis, FIP-fve and FIP-gts significantly reversed docetaxel-induced decreases in percent bone volume (BV/TV), trabecular number (Tb.N) and bone surface density (BS/TV) in mice. Moreover, monocyte chemoattractant protein-1 (MCP-1) production and mRNA expressions induced by docetaxel in A549 cells were diminished by FIP-fve and FIP-gts. Thus, FIP-fve and FIP-gts have the potential to mitigate docetaxel-induced adverse effects in patients undergoing chemotherapy and to serve as novel therapeutic protective agents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 19, Part A, December 2015, Pages 451–463
نویسندگان
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