کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1220157 1494545 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Isolation and identification of chromone and pyrone constituents from Aloe and their anti-inflammatory activities
ترجمه فارسی عنوان
جداسازی و شناسایی ترکیبات کروم و پریون از آلوئه و فعالیت ضد التهابی آن
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• Isolation of fifteen compounds from Aloe was performed.
• Aloe resin E (1) and aloenin C (11) were identified as new compounds.
• Three compounds exhibited the most prominent NF-κB inhibitory activity.
• A decrease in iNOS and ICAM-1 genes expression were confirmed.
• This is the first investigation of NF-κB inhibitors of Aloe.

Aloe has long been used in food products, beverages and cosmetics, and as a traditional medicine to treat various diseases in many countries. In the present study, a new chromone, aloe resin E (1), and a new pyrone, aloenin C (11), together with thirteen known compounds were isolated from aqueous dissolved Aloe exudates and their structures were identified by spectroscopic analysis. Nuclear factor kappa B (NF-κB) inhibitory activity of the isolated compounds was evaluated using an NF-κB luciferase assay in HepG2 cells. Among them, 7-hydroxy-5-(hydroxymethyl)-2-methylchromone (4), 5-((S)-2′-oxo-4′-hydroxypentyl)-2-hydroxymethylchromone (9), and aloenin aglycone (13) showed significant inhibitory effects against TNFα-induced NF-κB transcriptional activity in a dose-dependent manner with IC50 values ranging from 14.92 to 18.70 µM. Furthermore, the transcriptional inhibition of compounds 4, 9, and 13 was confirmed by a decrease in the expression of inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule-1 (ICAM-1) genes in HepG2 cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 21, March 2016, Pages 232–239
نویسندگان
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