کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1220385 | 967783 | 2013 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Antrodia camphorata ameliorates high-fat-diet induced hepatic steatosis via improving lipid metabolism and antioxidative status Antrodia camphorata ameliorates high-fat-diet induced hepatic steatosis via improving lipid metabolism and antioxidative status](/preview/png/1220385.png)
• Feeding mice with a high-fat diet for 36 weeks successfully induces NAFLD syndrome.
• Wild Antrodia camphoata (AC) decreases serum and liver lipids in NAFLD mice.
• Wild AC enhances liver antioxidative capacities in NAFLD mice.
• Wild AC decreases liver damage indices in NAFLD mice.
• Wild AC promotes lipid oxidation and energy expenditure via activating gene expressions of PPAR-α, CPT-1, CPT-2, and UCP-2.
Nonalcoholic fatty liver disease (NAFLD) commonly results from excessive dietary fat intake which characterized by obesity and insulin resistance. Wild fruiting body of Antrodia camphorata (AC) was assayed for alleviative effects on NAFLD. An NAFLD animal model was successfully established in male 7-week-old C57BL/6 mice fed with high-fat diet (HFD) for 36 weeks. The HFD mice exhibited obese and impaired glucose metabolism. After an induction of NAFLD syndrome, AC was given for one week via gavage. Mice with AC treatment showed lowered (p < 0.05) serum TG and TC, lowered (p < 0.05) liver TG content, improved (p < 0.05) oxidative status (TBARS values and GSH levels), and ameliorated (p < 0.05) liver damage (AST, ALT, and LDH values). In addition, AC activated (p < 0.05) gene expressions of PPAR-α with its downstream genes in the liver and caused higher (p < 0.05) rectal temperature, which showed AC attenuates hepatic lipid accumulation by promoting lipid oxidation and further suggests the role of AC in energy expenditure. Overall, our findings revealed that AC possesses alleviative effect on NAFLD.
Journal: Journal of Functional Foods - Volume 5, Issue 3, July 2013, Pages 1317–1325