کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1225821 968254 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tick salivary secretion as a source of antihemostatics
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Tick salivary secretion as a source of antihemostatics
چکیده انگلیسی

Ticks are mostly obligatory blood feeding ectoparasites that have an impact on human and animal health. In addition to direct damage due to feeding, some tick species serve as the vectors for the causative agents of several diseases, such as the spirochetes of the genus Borrelia causing Lyme disease, the virus of tick-borne encephalitis, various Rickettsial pathogens or even protozoan parasites like Babesia spp. Hard ticks are unique among bloodfeeders because of their prolonged feeding period that may last up to two weeks. During such a long period of blood uptake, the host develops a wide range of mechanisms to prevent blood loss. The arthropod ectoparasite, in turn, secretes saliva in the sites of bite that assists blood feeding. Indeed, tick saliva represents a rich source of proteins with potent pharmacologic action that target different mechanisms of coagulation, platelet aggregation and vasoconstriction. Tick adaptation to their vertebrate hosts led to the inclusion of a powerful protein armamentarium in their salivary secretion that has been investigated by high‐throughput methods. The resulting knowledge can be exploited for the isolation of novel antihemostatic agents. Here we review the tick salivary antihemostatics and their characterized functions at the molecular and cellular levels.

Figure optionsDownload high-quality image (283 K)Download as PowerPoint slideHighlights
► We explain why it is important for ticks to control host hemostasis.
► The hemostatic processes affected by tick salivary secretion are presented.
► The developments in the discovery of tick salivary proteins are highlighted.
► The different tick proteins that have antihemostatic function are reviewed.
► We abstract the mechanism of action of tick antihemostatics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Proteomics - Volume 75, Issue 13, 16 July 2012, Pages 3842–3854
نویسندگان
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