کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1226023 968268 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The cancer cell secretome: A good source for discovering biomarkers?
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
The cancer cell secretome: A good source for discovering biomarkers?
چکیده انگلیسی

Cancer is a leading cause of death. Early detection is usually associated with better clinical outcomes. Recent advances in genomics and proteomics raised hopes that new biomarkers for diagnosis, prognosis or monitoring therapeutic response will soon be discovered. Proteins secreted by cancer cells, referred also as “the cancer cell secretome”, is a promising source for biomarker discovery. In this review we will summarize recent advances in cancer cell secretome analysis, focusing on the five most fatal cancers (lung, breast, prostate, colorectal, and pancreatic). For each cancer type we will describe the proteomic approaches utilized for the identification of novel biomarkers. Despite progress, identification of markers that are superior to those currently used has proven to be a difficult task and very few, if any, newly discovered biomarker has entered the clinic the last 10 years.

(A) Phase contrast (I) and merge FRET-microscopy (II) images of cerebellar granule neurons stained with anti-L-VOCC/Alexa488-IgG and anti-Cb5R/Cy3-IgG. (B) Pixels analysis of neuronal somas: green (empty symbols) and red fluorescence (filled symbols).Figure optionsDownload high-quality image (578 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Proteomics - Volume 73, Issue 10, 10 September 2010, Pages 1896–1906
نویسندگان
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