کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1227153 968350 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biochemical and proteomic approaches for the study of membrane microdomains
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Biochemical and proteomic approaches for the study of membrane microdomains
چکیده انگلیسی

Many cellular signaling and communication events take place at the plasma membrane and thus the characterization of the plasma membrane proteome has been a hot research area in the hopes of learning more about these processes. Membrane microdomains are large protein and lipid complexes found on the cell surface membrane, able to concentrate or recruit signaling molecules or factors. The first step of any organelle proteomics study is to get a pure and enriched protein sample yet this has always been problematic in membrane proteomics as it is virtually impossible to purify a specific membrane type to homogeneity. In this review, we summarize the biochemical and proteomic approaches that have been used recently in the isolation and identification of several membrane microdomains and non-typical membrane proteins.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Proteomics - Volume 72, Issue 1, 15 February 2009, Pages 12–22
نویسندگان
, ,