کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1227968 | 968441 | 2010 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Flow injection chemiluminescence determination of isoniazid using luminol and silver nanoparticles Flow injection chemiluminescence determination of isoniazid using luminol and silver nanoparticles](/preview/png/1227968.png)
The effect of silver colloidal nanoparticles (AgNPs) on the luminol–isoniazid system was investigated. It was found that AgNPs could act as a nanocatalyst on the luminol–isoniazid system to generate chemiluminescence (CL). The CL emission spectrum of the luminol–isoniazid–AgNPs system showed a peak with a maximum at 425 nm. It was suggested that the luminophor species was the excited state 3-aminophthalate. The reduction of dissolved O2 to H2O2 by isoniazid and decomposition of H2O2 to the oxygen-related radicals were attributed to the catalytic effect of AgNPs. Under optimized conditions, the CL signal intensity was linear with the isoniazid concentration in the range of 10–1000 ng mL− 1, with the correlation coefficient of 0.9996. The limit of detection was 2.7 ng mL− 1 isoniazid. The relative standard deviations for seven repeated measurements of 60 and 200 ng mL− 1 isoniazid were 1.4 and 2.4%, respectively. The effect of potent interfering compounds on the CL signal intensity of the proposed luminol–isoniazid–AgNPs system was investigated. The proposed method was successfully applied to the determination of isoniazid in a pharmaceutical sample.
Journal: Microchemical Journal - Volume 95, Issue 2, July 2010, Pages 192–197