Synthesis, spectral studies and biological evaluation of 2-aminonicotinic acid metal complexes

• Synthesis of 2-aminonicotinic acid metal complexes
• Spectral and thermal studies
• Antibacterial, fungicidal and nematicidal activities of metal complexes

We synthesized 2-aminonicotinic acid (2-ANA) complexes with metals such as Co(II), Fe(III), Ni(II), Mn(II), Zn(II), Ag(I),Cr(III), Cd(II) and Cu(II) in aqueous media. The complexes were characterized and elucidated using FT-IR, UV–Vis, a fluorescence spectrophotometer and thermo gravimetric analysis (TGA). TGA data showed that the stoichiometry of complexes was 1:2 metal/ligand except for Ag(I) and Mn(II) where the ratio was 1:1. The metal complexes showed varied antibacterial, fungicidal and nematicidal activities. The silver and zinc complexes showed highest activity against Bacillus subtilis and Bacillus licheniformis respectively. Fusarium oxysporum was highly susceptible to nickel and copper complexes whereas Macrophomina phaseolina was completely inert to the complexes. The silver and cadmium complexes were effective against the root-knot nematode Meloidogyne javanica.

We report the synthesis of 2-aminonicotinic acid (2-ANA) metal complexes, their spectral studies and biological evaluation. Some complexes show interesting biological activities.Figure optionsDownload as PowerPoint slide