A rapid and sensitive assay for determination of doxycycline using thioglycolic acid-capped cadmium telluride quantum dots

• Rapid fluorescence determination of doxycycline was done using QDs.
• This method is simple and sensitive than other methods proposed for doxycycline determination.
• The proposed method requires inexpensive instrumentation and chemicals.

A rapid, simple and inexpensive spectrofluorimetric sensor for determination of doxycycline based on its interaction with thioglycolic acid-capped cadmium telluride quantum dots (TGA/CdTe QDs) has been developed. Under the optimum experimental conditions, the sensor exhibited a fast response time of <10 s. The results revealed that doxycycline could quench the fluorescence of TGA/CdTe QDs via electron transfer from the QDs to doxycycline through a dynamic quenching mechanism. The sensor permitted determination of doxycycline in a concentration range of 1.9 × 10−6–6.1 × 10−5 mol L−1 with a detection limit of 1.1 × 10−7 mol L−1. The sensor was applied for determination of doxycycline in honey and human serum samples.

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