Synthesis, spectroscopic, X-ray crystal structure, biological and DNA interaction studies of organotin(IV) complexes of 2-(4-ethoxybenzylidene) butanoic acid

• Synthesis of six organotin(IV) complexes of 2-(4-ethoxybenzylidene) butanoic acid.
• Spectroscopic characterization of synthesized complexes (1–6).
• Single crystal analysis of complex 1.
• Antimicrobial, cytotoxic and antitumor activities of complexes (1–6).
• DNA interaction studies by UV–Visible spectrophotometry and viscometry.

Six organotin(IV) carboxylates of the type R2SnL2 [R = CH3 (1), n-C4H9 (2), n-C8H17 (3)] and R3SnL [R = CH3 (4), n-C4H9 (5), C6H5 (6), where L = 2-(4-ethoxybenzylidene) butanoic acid, have been synthesized and characterized by elemental analysis, FT-IR and NMR (1H, 13C). The complex (1) was also analyzed by single crystal X-ray analysis. The complexes were screened for antimicrobial, cytotoxic and anti-tumor activities. The results showed significant activity in each area of the activity with few exceptions. DNA interactions studies of ligand HL and representative complex 2 were investigated by UV–Visible absorption spectroscopy and viscosity measurements. The results showed that both ligand HL and complex 2 interact with SS-DNA via intercalation as well as minor groove binding.

Six organotin(IV) complexes of 2-(4-ethoxybenzylidene) butanoic acid, have been synthesized, characterized and evaluated for antimicrobial, cytotoxic and anti-tumor activities. DNA interactions studies were performed to find out drug-DNA mechanism.Figure optionsDownload as PowerPoint slide