Synthesis of silver nanoparticles from Melia dubia leaf extract and their in vitro anticancer activity

• Melia dubia acting as both the reducing and stabilizing agents.
• Silver nanoparticles showed remarkable cytotoxicity.
• Its activity against KB cell line with evidence of high therapeutic index value.
• Green route synthesis of silver nanoparticles of 7.3 nm.

Silver nanoparticles have a significant role in the pharmaceutical science. Especially, silver nanoparticles synthesized by the plant extracts lead a significant role in biological activities such as antimicrobial, antioxidant and anticancer. Keeping this in mind, the present work investigation has been taken up with the synthesized silver nanoparticles using the plant extract of Melia dubia and it characterizes by using UV–visible, XRD and SEM–EDS. The effect of the silver nanoparticles on human breast cancer (KB) cell line has been tested. Silver nanoparticles showed remarkable cytotoxicity activity against KB cell line with evidence of high therapeutic index value are the results are discussed.

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