A fluorescence study on the interaction of telmisartan in triblock polymers pluronic P123 and F127

• Telmisartan resides in the corona of pluronic and experiences restricted diffusion.
• Quenching of telmisartan fluorescence is due to static and collisional interactions.
• Higher hydrophilic content in pluronic promotes complex formation.

Telmisartan is a poorly soluble drug used in treatment of hypertension. There is a recent interest to use pluronic for improving the solubility and bioavailability of these drugs. In this study the interaction of telmisartan with P123 and F127 has been carried out using steady state and time dependent fluorescence study. Quenching of telmisartan fluorescence by potassium iodide is controlled by interactions arising from collisions and complex formation. A comparison of the fluorescence of telmisartan in pluronics with the well understood fluorescence of 8-anilino-1-naphthalene-sulfonic acid, a known fluorescent molecular probe, indicates that telmisartan is generally present in a relatively polar microenvironment with restricted diffusive motion.

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