کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1230664 | 1495261 | 2013 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Determination of 6-thioguanine based on localized surface plasmon resonance of gold nanoparticle Determination of 6-thioguanine based on localized surface plasmon resonance of gold nanoparticle](/preview/png/1230664.png)
Gold nanoparticles exhibit the optical properties of localized surface plamon resonance (LSPR) and are widely applied to the biosensors. The application of gold nanoparticles to the determination of anticancer drug 6-thioguanine (6-TG) was discussed. The binding of 6-TG molecule to the surface of gold nanoparticles alters the local refractive index in the vicinity of the nanoparticles and results in a shift of the LSPR spectrum. The experimental conditions were examined and optimized. Under the optimal conditions, the ratios of absorbances at two wavelengths are directly proportional to the concentrations of 6-TG. The developed method is simple, rapid, and sensitive. In addition, this method is particularly attractive because organic cosolvents, light-sensitive dyes, and sophisticated instruments are not required. This method was successfully applied to the determination of 6-TG in real samples and the results were satisfactory.
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► 6-TG was determined based on localized surface plasmon resonance (LSPR) using gold nanoparticles as the probe.
► The proposed method is simple and sensitive.
► The sensitivity of gold nanorods was higher than gold nanospheres.
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 107, 15 April 2013, Pages 24–30