کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
12313 789 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of the surface modification of titanium using a recombinant fragment of fibronectin and vitronectin on cell behavior
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
The effect of the surface modification of titanium using a recombinant fragment of fibronectin and vitronectin on cell behavior
چکیده انگلیسی

The surface of titanium implants is in direct contact with host tissue and plays a critical role in determining biocompatibility. Fibronectin (FN) and vitronectin (VN) are major cell adhesive proteins found in the extracellular matrix (ECM) of various tissues, and in circulating blood. The aim of this study was to evaluate the engineered biomimetic surface of titanium by using recombinant fragment of FN8–10 and VNNTD that contains the binding site for integrins. MC3T3-E1 cells seeded upon the FN8−10-coated titanium showed a marked increase in cell adhesion, proliferation, and differentiation over VNNTD-coated titanium. In addition, we confirmed that the surface properties of titanium prefer for FN8–10 over VNNTD (p<0.05) in protein adhesion. These results suggest that the FN8–10-modified titanium surface can be used to improve the osseointegration of titanium implants by enhancing bone formation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 26, Issue 25, September 2005, Pages 5153–5157
نویسندگان
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