Study on the sonodynamic activity and mechanism of promethazine hydrochloride by multi-spectroscopic techniques

- The sonodynamic damage to protein in the presence of PMT was studied.
- BSA damage degree increases with ultrasonic irradiation time and PMT concentration.
- The synergistic effects of ultrasound and PMT induce the damage of BSA molecules.
- The damage of BSA molecules could be mainly due to the generation of ROS.
- The sonodynamic activity of PMT and its mechanism have not been reported so far.