کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1234192 968824 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, spectral and computational studies of some N-acyl-t(3)-isopropyl-r(2),c(6)-bis-2′-furylpiperidin-4-one oximes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Synthesis, spectral and computational studies of some N-acyl-t(3)-isopropyl-r(2),c(6)-bis-2′-furylpiperidin-4-one oximes
چکیده انگلیسی
Four N-acyl-t(3)-isopropyl-r(2),c(6)-bis-2′-furylpiperidin-4-one oximes 1-4 were synthesized and the high resolution 1H and 13C NMR spectra have been recorded at various temperatures and analyzed. The spectra reveal the presence of two rotameric forms (syn and anti) in solution. 1H-1H COSY and 1H-13C COSY spectra have been recorded to assist the assignment of the signals for the syn and anti isomers of 1-4. Coupling constants predict an equilibrium mixture of boat form B1 and alternate chair form CA for 1-4. The effect of varying the substituents at nitrogen and at C(4) on the 1H and 13C chemical shifts has been analyzed in detail. The molecular structures of the N-acyl derivatives 1-4 were also determined using AM1 Hamiltonian and the results have been compared to the results derived from spectral studies. Mass spectra have also been recorded for 1-4.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 75, Issue 1, January 2010, Pages 113-120
نویسندگان
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