Synthesis, spectral characterization and in vitro antimicrobial activity of some new azopyridine derivatives

A series of arylpicolino and/or isonicotinohydrazonyl cyanide 2a–d and 4a–f were prepared by coupling the approprite aryl diazonium salt with 2-cyanomethyl and/or 4-cyanomethyl-pyridine, respectively. These compounds were characterized by analytical and spectral analyses and screened for their antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and antifungal activity. Among the synthesized compounds, N′-(4-phenyldiazenyl)phenylisonicotinohydrazonyl cyanide 4f showed a significant activity toward both Gram-positive, Gram-negative bacteria and exhibit the most potent in vitro antifungal with MIC's (625 μg/mL) against Aspergillus nieger.

N′-(4-Phenyldiazenyl)phenylisonicotinohydrazonyl cyanide showed a significant activity toward bacteria and exhibit the most potent in vitro antifungal with MIC's against A. nieger.Figure optionsDownload as PowerPoint slideHighlights
► Synthesized compounds were characterized by analytical and spectral data.
► Compounds were screened for their antibacterial and antifungal activity.
► Compound 4f showed a significant activity towards both bacteria strains.
► Compound 4f exhibit the most potent antifungal with MIC's against A. nieger.