Study of the solvent effects on the molecular structure and CO stretching vibrations of flurbiprofen

► The solvent effects on ν(C=O) of FBF in different solvents are studied by FTIR. ► A linear correlation between calculated ν(C=O) and measured ν(C=O) was obtained. ► A poor correlation between ν(C=O) of FBF and the AN and KBM is observed. ► The LSER offers explanation of solvent-induced stretching frequency shifts.