Solvent effects on infrared spectroscopy of 17β-hydroxy-17-methyl-2-oxa-5α-androstan-3-one in single solvents

Infrared spectroscopy studies of 17β-hydroxy-17-methyl-2-oxa-5α-androstan-3-one (HMOA) in 20 different pure organic solvents were undertaken to investigate the solute-solvent interactions and to correlate solvent properties, such as the KBM equation, the solvent acceptor number (AN), Schleyer's linear free energy equation (G-value), Dimroth and Reichardt's parameter ET(30) and Brownstein's parameter S with the frequency shifts of the carbonyl stretching vibration for solute. The result indicated that the KBM relationship is unsuitable to the complicated molecules. These frequencies exhibited a better correlation with the solvent parameters AN and G-value than others.