Molecular complexes of ketaconazole and oxatomide with p-chloranil: Spectroscopic and spectrofluorimetric studies

The molecular complexes of the donors ketaconazole (KTZ) and oxatomide (OXA) drugs with 2,3,5,6-tetrachloro-1,4-benzoquinone (p-chloranil, p-CHL) have been investigated spectroscopically (UV–vis, FT-IR and 1H NMR) and spectrofluorimetrically in different solvents and temperatures. The stoichiometry of the complexes was found to be 1:1. The data are discussed in terms of formation constant, molar extinction coefficient, oscillator strength, dipole moment, ionization potential, dissociation energy and thermodynamic parameters. The results indicated that the formation of molecular complex is spontaneous and endothermic. The fluorescence quenching studies indicated that the interaction of the donors is spontaneous and the fluorescence quenching increased with an increase in the intensity of complexation with the acceptor.

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► Structural characterization of molecular complexes of two drugs has been studied.
► The point of attachment of these drugs with the acceptor has been spectroscopically established.
► The formation of 1:1 molecular complex is spontaneous and endothermic.