کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1236734 968874 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation and characterization of inclusion complexes of pefloxacin mesylate with three kinds of cyclodextrins
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Preparation and characterization of inclusion complexes of pefloxacin mesylate with three kinds of cyclodextrins
چکیده انگلیسی

The ability of α-cyclodextrin, β-cyclodextrin and hydroxypropyl-β-cyclodextrin (α-CD, β-CD and HP-β-CD) to break pefloxacin mesylate (PM) aggregates by forming inclusion complexes has been studied using 1H NMR (nuclear magnetic resonance spectroscopy), 13C NMR and fluorescence spectra. The inclusion constants are determined to compare the corresponding inclusion capacity. Solid-inclusion complexes of PM with CDs are synthesized by coprecipitation method, and all the inclusion ratios are found to be 1:1. Additionally, spatial characterization of complexes has been proposed based on two-dimensional nuclear magnetic resonance technique (2D NMR) and spatial conformation is also investigated to propose two possible models between PM and CDs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 64, Issue 1, 1 May 2006, Pages 166–170
نویسندگان
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