Fluorescence and dynamic light scattering studies of niosomes-membrane mimetic systems

Niosomal vesicles are more stable than liposomal vesicles due to higher chemical stability of surfactants compared to phospholipids. Niosomes have been prepared from Span20, Span80, Tween20 and Tween80. Fluorescence resonance energy transfer studies have been performed in these systems to determine donor–acceptor distances. It has been found that the fluorescence resonance energy transfer efficiency is better in niosomes compared to micelles. The formation of niosomes is guided by the hydrophile–lipophile balance value of the nonionic surfactant.