کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1251745 1496294 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro oxidation of LDL by ozone
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
In vitro oxidation of LDL by ozone
چکیده انگلیسی


• We show that ozone is capable of oxidizing low-density lipoprotein (LDL).
• LPO, TBARS, REM, and oxidation-specific epitopes increase upon LDL oxidation by ozone.
• Ozonization of LDL may be a novel pathway which supports atherogenesis.

Recent studies suggest that ozone is present in atherosclerotic lesions. Since these lesions are characterized by a dramatic accumulation of low-density lipoprotein (LDL), we aimed to investigate whether ozone is capable of oxidizing LDL, thereby rendering this lipoprotein atherogenic. Lipid hydroperoxide (LPO) concentrations and thiobarbituric acid reactive substances (TBARS) were measured to assess the oxidative status of the lipid part of LDL. Relative electrophoretic mobility (REM) and oxidation-specific immune epitopes were measured to assess the oxidative status of the protein part (apoB) of the LDL particle. Ozone turned out to be a potent oxidant of LDL. LPO concentrations, TBARS, REM, and oxidation-specific immune epitopes significantly increased upon ozonization. Our results suggest that ozonization of LDL may be a novel pathway which supports atherogenesis. Ozone is capable of oxidizing the lipid part of LDL, followed by immediate oxidation of the protein part of LDL, rendering the lipoprotein atherogenic.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemistry and Physics of Lipids - Volume 183, October 2014, Pages 18–21
نویسندگان
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