کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1252399 | 1496348 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Study of thermodynamic parameters for solubilization of plant sterol and stanol in bile salt micelles
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We investigated the difference between the molecular structures of plant sterols and stanols that affect the solubilization of cholesterol in bile salt micelles (in vitro study). First, the aqueous solubility of β-sitosterol, β-sitostanol, and campesterol was determined by considering the specific radioactivity by using a fairly small quantity of each radiolabeled compound. The order of their aqueous solubilities was as follows: cholesterol > campesterol > β-sitostanol > β-sitosterol. The maximum solubility of cholesterol and the abovementioned sterol/stanol in sodium taurodeoxycholate and sodium taurocholate solutions (single solubilizate system) was measured. Moreover, the preferential solubilization of cholesterol in bile salt solutions was systematically studied by using different types of plant sterols/stanols. The solubilization results showed that the cholesterol-lowering effect was similar for sterols and stanol. Thermodynamic analysis was applied to these experimental results. The Gibbs energy change (ÎG°) for the solubilization of plant sterols/stanols showed a negative value larger than that for cholesterol.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemistry and Physics of Lipids - Volume 154, Issue 2, August 2008, Pages 87-93
Journal: Chemistry and Physics of Lipids - Volume 154, Issue 2, August 2008, Pages 87-93
نویسندگان
Keisuke Matsuoka, Tomomi Nakazawa, Ai Nakamura, Chikako Honda, Kazutoyo Endo, Masamichi Tsukada,