Functional lipidomics of oxidized products from polyunsaturated fatty acids

Because of their high degree of unsaturation, polyunsaturated fatty acids (PUFA) in mammals, with mainly 18, 20 and 22 carbons, can easily be autooxidized, and converted into many oxidized derivatives and degradation products. This short review reports on some of those relevant to the evaluation of oxidative stress in situ. In addition, the enzyme-dependent oxygenation by both dioxygenases and monooxygenases is briefly reviewed by functional and/or metabolic categories, pointing out the structure variety and the analytical approaches.

► This short review deals with oxidized products of polyunsaturated fatty acids.
► First, autooxidation is considered with the comparison of various markers.
► Then, cyclooxygenase- and lipoxygenase-dependent oxidations are shown.
► Finally, cytochrome P450/monooxygenase products are described.
► The metabolites are presented in a functional and targeted lipidomics approach.