کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1253667 | 1496343 | 2009 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Molecular dynamics study of a phospholipid monolayer at a water/triglyceride interface: towards lipid emulsion modelling Molecular dynamics study of a phospholipid monolayer at a water/triglyceride interface: towards lipid emulsion modelling](/preview/png/1253667.png)
In order to mimic the surface of parenteral nutrition emulsion droplets, the first molecular dynamics simulation of a palmitoyloleoylphosphatidylcholine (POPC) monolayer at a water/triglyceride (trilinoleoylglycerol, LLL) interface was performed. Triglyceride influence was evaluated by comparing computed phospholipid properties to the ones in a similarly modelled hydrated POPC bilayer. As expected, polar head properties (molecular area, lipid hydration, headgroup orientation) were not affected by triglycerides. In contrast, slight differences were observed on phospholipid alkyl tail region (order parameter, diffusion, Van der Waals interactions). This first approach can reasonably be extended to a further more realistic multicomponent model of clinical nutrition emulsions.
Journal: Chemistry and Physics of Lipids - Volume 157, Issue 2, February 2009, Pages 86–93