Sphingolipids with neuritogenic activity from Euphorbia sororia

Two groups of sphingolipids 1 and 2 were isolated from the aerial parts of Euphorbia sororia. On the basis of spectroscopic data, chemical methods and GC-MS analysis, the structures of 1 and 2 were characterized as 1-O-β-d-glucopyranosyl-(2S,3S,4R,8Z)-2-[(2′R)-2′-hydroxydocosanoyl∼hexacosanoyl, octacosanoyl amino]-1,3,4-octadecanetriol-8-ene and (2S,3S,4R,8E)-2-[(2′R)-2′-hydroxyeicosanoyl∼hexacosanoyl amino]-1,3,4-octadecanetriol-8-ene, respectively. Both of them exhibited marked neuritogenic activity on the rat pheochromocytoma PC12 cell line.