GAG-containing nucleotides as mediators of DNA-silver clusters and iron-DNA interplay

New types of fluorescence DNA-based silver nanoclusters (DNAn-AgNCs, n = 1, 2, 3c, 4c, 5c) were synthesized by C3T-rich nucleotides as templates. It is found that the assembly of DNAn-AgNCs with nucleotides containing GAG sequences produce silver clusters with an enhanced red emission. Results indicate that GAG is the good enhancer of DNAn-AgNCs constructed by C3T-rich nucleotides. The fluorescence titration reveals that enhanced red emission is sensitive to Fe(III/II) ions with the formation of non-emission nanoclusters. Thus, the GAG-containing nucleotide can be an enhancer for the emission of silver clusters with C3T-rich nucleotide and a mediator of the iron-cluster interplay.

GAG-containing nucleotides were found to be enhancers for the emission of silver clusters with C3T-rich nucleotides and mediators of the Fe(III)-cluster interplay.Figure optionsDownload as PowerPoint slide