کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1255074 971405 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing
چکیده انگلیسی

A membrane composed of an alginate (ALG) layer and a chitosan (CHS) layer with sustained antimicrobial efficacy was prepared. Ciprofloxacin HCl (CIP) was incorporated into the ALG layer. Morphological feature of the composite membrane was analyzed by scanning electron microscopy (SEM). Water uptake capacity, invitro drug release, and in vitro antimicrobial activity were evaluated. The composite membrane exhibited perfect binding characteristic between the two layers. The water uptake capacity of all the membranes was above 800%. The CIP could release from the composite membranes for 48 h. The membrane could control the bacterial growth persistently. The results suggested that this CHS/ALG composite membrane incorporated with CIP had the potential for wound dressing application.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 21, Issue 8, August 2010, Pages 1011–1014
نویسندگان
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