کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1256670 971520 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytokine–receptor interactions as drug targets
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Cytokine–receptor interactions as drug targets
چکیده انگلیسی

Cytokines are essential proteins that exert potent control over entire cell populations to fight infections and other pathologies, but can by themselves cause disease. Therefore, cytokine-related drugs act either by stimulating or blocking their activities. Our knowledge of the structures of cytokine–receptor complexes, the biophysical basis of their binding, and their mode of biological activation has substantially increased in recent years. This knowledge has been translated into new drugs and drug candidates. This review summarizes our current understanding of the receptor-mediated activity of cytokines, their relation to health and disease, and the agents in use to activate and block their actions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 14, Issue 4, August 2010, Pages 511–519
نویسندگان
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