کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1256720 | 971527 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthetic receptors with antibody-like binding affinities
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
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چکیده انگلیسی
Antibodies are critical reagents in biological research and are increasingly being developed as therapeutic agents. They typically exhibit very high affinity and selectivity for their ligands. Synthetic protein-binding agents rarely achieve the combination of high affinity and selectivity for their target protein that is typical of a good antibody. However, significant efforts are underway to develop a new generation of protein ligands with improved properties. This article reviews progress towards this goal and suggests fruitful strategies for future research.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 14, Issue 6, December 2010, Pages 713–720
Journal: Current Opinion in Chemical Biology - Volume 14, Issue 6, December 2010, Pages 713–720
نویسندگان
Thomas Kodadek,