کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1256882 971535 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure-based virtual screening of chemical libraries for drug discovery
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Structure-based virtual screening of chemical libraries for drug discovery
چکیده انگلیسی

One of the main goals in drug discovery is to identify new chemical entities that have a high likelihood of binding to the target protein to elicit the desired biological response. To this end, virtual screening is being increasingly used as a complement to high-throughput screening to improve the speed and efficiency of the drug discovery and development process. The availability of inexpensive high-performance computing platforms in recent years has transformed this field into one that is highly diverse and rapidly evolving, where large chemical databases have been successfully screened to identify hits for a wide range of targets such as Bcl-2 family proteins, G protein-coupled receptors, kinases, metalloproteins, nuclear hormone receptors, proteases and many more.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 10, Issue 3, June 2006, Pages 194–202
نویسندگان
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