کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1256891 971535 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enzymatic tools for engineering natural product glycosylation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Enzymatic tools for engineering natural product glycosylation
چکیده انگلیسی

Glycosylated natural products have served as reliable platforms for the development of many existing front-line drugs. In an effort to explore the contribution of the sugar constituents of these compounds, research groups have focused upon the development of chemical and enzymatic tools to diversify natural product glycosylation. Among the complementary routes available, in vivo pathway engineering, also referred to as ‘combinatorial biosynthesis’, is an emerging method that relies upon the co-expression of sugar biosynthetic gene cassettes and glycosyltransferases in a host organism to generate novel glycosylated natural products. An overview of recent progress in combinatorial biosynthesis is highlighted in this review, emphasizing the elucidation of nucleotide-sugar biosynthetic pathways and recent developments on glycosyltransferases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 10, Issue 3, June 2006, Pages 263–271
نویسندگان
, ,