کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1256999 971540 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular and functional analysis using live cell microarrays
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Molecular and functional analysis using live cell microarrays
چکیده انگلیسی

Understanding cellular behavior in both healthy and diseased states requires the ability to molecularly delineate the characteristics of individual cells from complex mixtures. The recent development of cellular microarrays allows such an undertaking. By immobilizing different cell capture and analysis reagents on a solid support, mixtures of cells can be rapidly interrogated for their composition and phenotype. Thus, one can identify and quantitate distinct cell types based on the expression of particular cell surface molecules, as well as analyze their response to defined signals through the secretion of specific factors or other measurable cellular activities. This review focuses on the use of cellular microarrays to detect antigen-specific T cells and their responsiveness, analyze cancer cell types and behavior and to investigate the control of stem cell differentiation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 10, Issue 1, February 2006, Pages 28–34
نویسندگان
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