کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1257156 971548 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of responsive lanthanide probes for cellular applications
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Development of responsive lanthanide probes for cellular applications
چکیده انگلیسی

Useful probes of the intracellular environment are required for a wide range of bioactive species including metal ions, oxyanions and pH. These probes need to be targeted to specific organelles (mitochondria, nucleus and lysosomes) in order to allow direct observation of the changes in these regions. Critical probe design features for luminescent lanthanide complexes are defined, together with a review of published sub-cellular localisation profiles. Cell uptake by macropinocytosis has been demonstrated for a wide range of probes and the importance of minimising perturbation of cellular homeostasis emphasised, so that cell viability, proliferation and membrane permeability are not compromised.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 14, Issue 2, April 2010, Pages 238–246
نویسندگان
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