کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1257180 | 971549 | 2013 | 4 صفحه PDF | دانلود رایگان |

Simplified aminocoumarin analogues, either noviosylated or simple basic heterocycle attached 3-amido-coumarin compounds, are known to be promising anticancer agents targeting the C-terminal ATP-binding site of Hsp90. In this study, 3′-amino isosteric replacement in the noviose moiety of two known noviose containing Hsp90 C-terminal inhibitors was synthetically realized for the first time. In vitro evaluation of these compounds suggested that the introduction of a basic amino group into the noviose subunit resulted in significant improvement of their cytotoxicities.
A novel series of simplified aminocoumarin analogues with the 3′-NH2 isosteric replacement in the noviose appendage were synthesized and evaluated.Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 24, Issue 8, August 2013, Pages 719–722