Keywords: مهار کننده های HSP90; Heat shock protein 90; Hsp90 inhibitors; Novobiocin analogues; Breast cancer;
مقالات ISI مهار کننده های HSP90 (ترجمه نشده)
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Design, synthesis and pharmacological evaluation of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-arylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamides as potent Hsp90 inhibitors
Keywords: مهار کننده های HSP90; Hsp90 inhibitors; CETSA; Molecular dynamics simulation; Apoptosis; IKK; (R)-Tic; (R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; GA; geldanamycin; BnBr; Benzyl bromide; CETSA; cellular thermal shift assay; DMEM; Dulbecco's modified Eagle's medium; R
Research paperSpontaneous assembly of HSP90 inhibitors at water/octanol interface: A molecular dynamics simulation study
Keywords: مهار کننده های HSP90; HSP90 inhibitors; Water/octanol interface; Molecular dynamics simulation;
Modified biphenyl Hsp90 C-terminal inhibitors for the treatment of cancer
Keywords: مهار کننده های HSP90; Breast cancer; Prostate cancer; Heat Shock Protein 90; Hsp90 inhibitors; Novobiocin analogs;
C15-methoxyphenylated 18-deoxy-herbimycin A analogues, their in vitro anticancer activity and heat shock protein 90 binding affinity
Keywords: مهار کننده های HSP90; Hsp90 inhibitors; Anticancer activity; Herbimycin A; C18-deoxy analogue; C15-phenylated analogue;
Synthesis and evaluation of 4-(2-hydroxypropyl)piperazin-1-yl) derivatives as Hsp90 inhibitors
Keywords: مهار کننده های HSP90; Hsp90 inhibitors; Structure-activity relationships; Structure-based drug design;
Novel 1,6-naphthyridin-2(1H)-ones as potential anticancer agents targeting Hsp90
Keywords: مهار کننده های HSP90; Heat shock protein 90; Hsp90 inhibitors; Novobiocin analogs; 1,6-Naphthyridin-2(1H)-ones; Breast cancer;
Discovery of an l-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100
Keywords: مهار کننده های HSP90; Prodrugs; Hsp90 inhibitors; Salt screening; Clinical candidate; Chromatography-free synthesis;
Exploring in vitro and in vivo Hsp90 inhibitors activity against human protozoan parasites
Keywords: مهار کننده های HSP90; Heat shock protein inhibitors; Hsp90 inhibitors; Trypanosoma brucei rhodesiense; Plasmodium falciparum; 1,2,3-Triazole; 3,4-Isoxazolediamide
Prediction of dual agents as an activator of mutant p53 and inhibitor of Hsp90 by docking, molecular dynamic simulation and virtual screening
Keywords: مهار کننده های HSP90; Hsp90, heat shock protein90; MDs, molecular dynamic simulations; Rg, radius of gyration; RMSD, root mean square deviation; RMSF, root mean square fluctuation; VS, virtual screeningDocking; Dual agent; Hsp90 inhibitors; Molecular dynamic simulations; P53;
Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold
Keywords: مهار کننده های HSP90; Hsp90 inhibitors; Structure-activity relationships; Structure-based drug design;
Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases
Keywords: مهار کننده های HSP90; HSP90 inhibitors; Isoform selectivity; Structure-based drug design; GRP94; TRAP1; Huntington's disease; Huntingtin;
Novologues containing a benzamide side chain manifest anti-proliferative activity against two breast cancer cell lines
Keywords: مهار کننده های HSP90; Heat shock protein 90; Hsp90 inhibitors; Novobiocin analogues; Breast cancer;
Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening
Keywords: مهار کننده های HSP90; Hsp90 inhibitors; ROCS; Design and synthesis
Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors
Keywords: مهار کننده های HSP90; Fragment based hit discovery; FAXS-NMR screening; Structure-based design; Hsp90 inhibitors; Anti-cancer agents
The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE
Keywords: مهار کننده های HSP90; PU-H71; HSP90 inhibitors; Glial activation; EAE; Astrocytes; Microglia;
A rat retinal damage model predicts for potential clinical visual disturbances induced by Hsp90 inhibitors
Keywords: مهار کننده های HSP90; Hsp90 inhibitors; Visual impairment; Retinal degeneration; Drug safety assessment; Predictive toxicology; Rodent model;
Hsp90 inhibitors in breast cancer: A systematic review
Keywords: مهار کننده های HSP90; Breast cancer; Hsp90 inhibitors; Tanespimycin; Alvespimycin; Retaspimycin;
Targeting the molecular chaperone heat shock protein 90 (HSP90): Lessons learned and future directions
Keywords: مهار کننده های HSP90; HSP90; HSP90 inhibitors; Molecular chaperone; Molecularly targeted therapy;
Simplified aminocoumarin analogues as anticancer agents: Amino isosteric replacement in the noviose moiety resulted in substantial enhancement of antiproliferative activity
Keywords: مهار کننده های HSP90; 3-Amino-3-deoxy-l-noviose; Aminocoumarin analogues; Cytotoxicity; Hsp90 inhibitors
Dimeric and trimeric triazole based molecules as a new class of Hsp90 molecular chaperone inhibitors
Keywords: مهار کننده های HSP90; Docking; Hsp90 inhibitors; Molecular chaperone; Triazole derivatives
Breast cancer and HSP90 inhibitors: Is there a role beyond the HER2-positive subtype?
Keywords: مهار کننده های HSP90; HSP molecular chaperone; HSP90 inhibitors; Breast cancer; HER2-positive; Hormonal receptor positive; Triple negative
Discovery and development of natural heat shock protein 90 inhibitors in cancer treatment
Keywords: مهار کننده های HSP90; Heat shock protein 90 (Hsp90); Tumor; Hsp90 inhibitors; Geldanamycin
Isoxazolo(aza)naphthoquinones: A new class of cytotoxic Hsp90 inhibitors
Keywords: مهار کننده های HSP90; Synthesis; Isoxazolonaphthoquinones; Hsp90 inhibitors; Antitumour; Antiproliferative activity; QSAR
Role of Additional Novel Therapies in Myeloproliferative Neoplasms
Keywords: مهار کننده های HSP90; JAK2-V617F; HDAC inhibitor; hsp90 inhibitors; PI3K/AKT inhibitor; MEK inhibitor; Myeloproliferative neoplasms;
Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model
Keywords: مهار کننده های HSP90; Hsp90 inhibitors; Chaperone inhibitors; Ortho-aminobenzamides; N-terminal ATP-binding site; Macrocycles; Buchwald–Hartwig cyclization
Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity
Keywords: مهار کننده های HSP90; Hsp90 inhibitors; Chaperon inhibitors; ortho-Aminobenzamides; N-terminal ATP-binding site; Macrocycles; Buchwald–Hartwig cyclization
Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors
Keywords: مهار کننده های HSP90; Hsp90 inhibitors; Cancer; 2,4-Diaminoquinazolines
Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model
Keywords: مهار کننده های HSP90; Hsp90 inhibitors; Chaperone inhibitors; ortho-Aminobenzamides; N-terminal ATP-binding site; Macrocycles; Buchwald–Hartwig cyclization
Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity
Keywords: مهار کننده های HSP90; Hsp90 inhibitors; Ortho-aminobenzamides; Tumor exposure; Macrocycles; Buchwald–Hartwig cyclization
Identification and initial SAR of silybin: An Hsp90 inhibitor
Keywords: مهار کننده های HSP90; Heat shock protein 90; Hsp90 inhibitors; Silybin; Structure–activity relationships; Breast cancer
Protection of oligodendrocyte precursor cells by low doses of HSP90 inhibitors in cell culture
Keywords: مهار کننده های HSP90; 17-AAG, 17-allylamino-17-demethoxygeldanamycin; HSP90, heat shock protein 90; OPCs, oligodendrocyte precursor cells17-allylamino-17-demethoxygeldanamycin; Heat shock protein 90; HSP90 antibodies; HSP90 beta; HSP90 inhibitors; O-2A cells; Cell death; Oligo
Hsp90-functionalized polypyrrole nanotube FET sensor for anti-cancer agent detection
Keywords: مهار کننده های HSP90; Hsp90; Hsp90 inhibitors; Field-effect transistor; Conducting polymer; Nanotube; Anti-cancer agents
Determination of PF-04928473 in human plasma using liquid chromatography with tandem mass spectrometry
Keywords: مهار کننده های HSP90; PF-04928473; PF-04929113; Hsp90 inhibitors; SNX-2112; SNX-5422
Identification of new Hsp90 inhibitors by structure-based virtual screening
Keywords: مهار کننده های HSP90; Hsp90 inhibitors; Anti-cancer drug; Virtual screening; Pyrimidine-2,4,6-trione; 4H-1,2,4-triazole-3-thiol
High cytotoxic sensitivity of the oligodendrocyte precursor cells to HSP90 inhibitors in cell cultures
Keywords: مهار کننده های HSP90; 17-AAG, 17-allylamino-17-demethoxygeldanamycin; GFAP, glial fibrillary acidic protein; HSP90, heat shock protein 90; OPCs, oligodendrocyte precursor cellsHeat shock protein 90; HSP90 inhibitors; Geldanamycin; 17-allylamino-17-demethoxygeldanamycin; Radici
Tosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23
Keywords: مهار کننده های HSP90; p23; Molecular cochaperone; hsp90; hsp90 inhibitors; Novobiocin; ER stress; RNA interference; Heat shock protein 90; Cell cycle; Apoptosis;
Discovery of 5-substituted 2-amino-4-chloro-8-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7,8-dihydropteridin-6(5H)-ones as potent and selective Hsp90 inhibitors
Keywords: مهار کننده های HSP90; Hsp90 inhibitors
Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells
Keywords: مهار کننده های HSP90; hsp90 inhibitors; Novobiocin; Coumarins; Apoptosis; Cell-cycle arrest
Regulators of endothelial and epithelial barrier integrity and function in acute lung injury
Keywords: مهار کننده های HSP90; ALC; alveolar liquid clearance; ALI; acute lung injury; ARDS; acute respiratory distress syndrome; BALF; broncholaveolar lavage fluid; DISC; death inducing signaling complex; Hsp90; heat shock protein 90; iNOS; inducible nitric oxide synthase; MLC; myosin
Assessing the chemical diversity of an hsp90 database
Keywords: مهار کننده های HSP90; Heat shock protein 90; hsp90 inhibitors; Molecular descriptors; Chemical fragments; Chemical diversityAkt, protein kinase B (also PKB); Her-2, human epidermal growth factor receptor 2 (also ErbB-2); c-Met, hepatocyte growth factor receptor (HGFR); Flt3, F
A novel class of Hsp90 inhibitors isolated by structure-based virtual screening
Keywords: مهار کننده های HSP90; Hsp90 inhibitors; Cancer; 3-Phenyl-2-styryl-3H-quinazolin-4-one; Virtual screening; Drug design;
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors
Keywords: مهار کننده های HSP90; Hsp90 inhibitors; Cancer; Pyrazole; Resorcinol; Protein crystal structure