کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5824149 | 1118430 | 2009 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulators of endothelial and epithelial barrier integrity and function in acute lung injury
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کلمات کلیدی
HSP90TNF receptor associated factor 2TNF-alpha converting enzymeNF-ATMLCARDSTACETRAF2DISCPPARiNOSSTATs - STATSATP - آدنوزین تری فسفات یا ATPAcute lung injury - آسیب ریه حادAlc - آلکPPAR agonists - آگونیست های PPARAli - اماBALF - بافتTER - داشتنmyosin light chain - زنجیره سبک میوزینinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییAcute respiratory distress syndrome - سندرم دیسترس تنفسی حادNuclear Factor of Activated T Cells - عامل هسته ای سلول های T فعال شدهsignal transducers and activators of transcription - مبدل سیگنال و فعال کننده رونویسیMetallothioneins - متالوتیژیونdeath inducing signaling complex - مرگ و میر ناشی از سیگنالینگ پیچیدهtransendothelial electrical resistance - مقاومت الکتریکی transendothelialHSP90 inhibitors - مهار کننده های HSP90Heat shock protein 90 - پروتئین شوک حرارت 90peroxisome proliferator-activated receptor - گیرنده فعال فعال پروکسیوم
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Permeability edema is a life-threatening complication accompanying acute lung injury (ALI), severe pneumonia and the acute respiratory distress syndrome (ARDS), which can be associated with a reduced alveolar liquid clearance (ALC) capacity, a disruption of the alveolar epithelial barrier, and an increased capillary endothelial permeability. Bacterial and viral infections can directly promote pulmonary endothelial hyperpermeability and indirectly decrease the function and/or expression of ion transporters regulating ALC in type II alveolar epithelial cells, by means of inducing a strong inflammatory and oxidative stress response in the infected lungs. Apart from ventilation strategies, no standard treatment exists for permeability edema, making the search for novel regulators of endothelial and epithelial hyperpermeability and dysfunction important. Here, we present an overview of recently identified substances that inhibit and/or reverse endothelial barrier disruption and permeability or alveolar epithelial dysfunction: (1) zinc chelators, which were shown to attenuate the effects of oxidative stress on the pulmonary endothelium; (2) peroxisome proliferator activated receptor (PPAR) ligands, which have been shown to exert anti-inflammatory effects, by decreasing the expression of pro-inflammatory genes; (3) extracellular ATP, produced during inflammation, which induces a rapid and dose-dependent increase in transendothelial electrical resistance (TER) across pulmonary endothelial cells; (4) the lectin-like domain of TNF, which is spatially distinct from the receptor binding sites and which protects from hydrostatic and permeability edema and (5) Hsp90 inhibitors, which prevent and repair toxin-induced hyperpermeability. Unraveling the mechanism of action of these agents could contribute to the development of novel therapeutic strategies to combat permeability edema.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 77, Issue 12, 15 June 2009, Pages 1763-1772
Journal: Biochemical Pharmacology - Volume 77, Issue 12, 15 June 2009, Pages 1763-1772
نویسندگان
Rudolf Lucas, Alexander D. Verin, Stephen M. Black, John D. Catravas,