کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374336 981917 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification and initial SAR of silybin: An Hsp90 inhibitor
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Identification and initial SAR of silybin: An Hsp90 inhibitor
چکیده انگلیسی

Through Hsp90-dependent firefly luciferase refolding and Hsp90-dependent heme-regulated eIF2α kinase (HRI) activation assays, silybin was identified as a novel Hsp90 inhibitor. Subsequently, a library of silybin analogues was designed, synthesized and evaluated. Initial SAR studies identified the essential, non-essential and detrimental functionalities on silybin that contribute to Hsp90 inhibition.Figure optionsDownload as PowerPoint slide

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 9, 1 May 2011, Pages 2659–2664
نویسندگان
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