کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1257191 971549 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CeCl3·7H2O-SiO2: Catalyst promoted microwave assisted neat synthesis, antifungal and antioxidant activities of α-diaminophosphonates
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
CeCl3·7H2O-SiO2: Catalyst promoted microwave assisted neat synthesis, antifungal and antioxidant activities of α-diaminophosphonates
چکیده انگلیسی

CeCl3·7H2O supported on silica (CeCl3·7H2O-SiO2) is used as a heterogeneous, efficient and recyclable catalyst for a three component one-pot reaction of an amine, aldehydes and diethyl phosphite to synthesize α-diaminophosphonate derivatives under microwave irradiation exploiting neat reaction conditions. Ten α-diaminophosphonates (6a–j) of 4,4′-sulfonyldianiline (Dapsone) (3) were synthesized and structural elucidation was confirmed by spectral data. Antifungal and antioxidant activities were evaluated include minimum inhibitory concentrations and IC50 values, respectively of the titled compounds. Compounds 6h, 6i exhibited promising antioxidant activity at lower IC50 values 53.7 μg/mL, 53.2 μg/mL, respectively as compared with standard IC50 value 51.6 μg/mL.

CeCl3·7H2O-SiO2 is an efficient and recyclable catalyst for a three component one-pot reaction of an amine, aldehydes and diethyl phosphite to synthesize α-diaminophosphonate derivatives under microwave irradiation exploiting neat reaction conditions.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 24, Issue 8, August 2013, Pages 759–763
نویسندگان
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