کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1257256 971553 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Profiling protein tyrosine phosphatase activity with mechanistic probes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Profiling protein tyrosine phosphatase activity with mechanistic probes
چکیده انگلیسی

The protein tyrosine phosphatases are a family of enzymes that play critical roles in regulating physiological processes including cellular signaling, growth, differentiation, and the immune response. As new roles emerge for these enzymes in human disease, interest in understanding their mechanism of regulation and function has increased correspondingly. The recent development of mechanism-based probes for phosphatase activity has paved the way for detailed studies of tyrosine phosphatase activity and regulation in both physiological and pathological cellular signaling.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 13, Issue 4, October 2009, Pages 375–381
نویسندگان
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